• Does your bladder impairs your quality of life?
  • Do you suffer from urgency which is difficult to suppress?
  • Do you often feel the need to go to the toilet – even several times a night?
  • Do you have severe persistent pain in your lower abdomen?

If the answer to one or more questions is yes, you may have chronic inflammation of the bladder, or chronic cystitis.

Chronic bladder inflammation causes three main symptoms:

How does chronic cystitis develop?


A healthy bladder has a fine mucous protective layer that stops irritant substances in the urine from reaching the bladder wall. In chronic forms of cystitis this protective lining, known as the glycosaminoglycan layer (or GAG-layer), becomes damaged, so it fails to protect the bladder wall. Once this barrier is damaged, irritants from urine can reach the underlying structures and aggravate the neurons. This causes the symptoms we discussed above.

How can Gepan help?

Gepan is a pH neutral, sterile solution, containing chondroitin sulphate (0.2%), a natural component of the GAG layer.

Mode of action

Gepan attaches to the damaged areas of the bladder wall, just like a liquid bandage adheres onto a wound. As a result, the protective layer is restored, preventing the penetration of irritants into the deeper tissue. As a result, the bladder is protected from irritants in the urine and cystitis symptoms are reduced.

Gepan’s effectiveness, safety and tolerability are confirmed by 286 patients with chronic cystitis.* The study showed that all the main symptoms (pain, urgency and frequency) were significantly reduced after three months of treatment. In addition to that, both doctors (84%) and patients (82%) were highly satisfied by the treatment.