- Does your bladder impairs your quality of life?
- Do you suffer from urgency which is difficult to suppress?
- Do you often feel the need to go to the toilet – even several times a night?
- Do you have severe persistent pain in your lower abdomen?
If the answer to one or more questions is yes, you may have chronic inflammation of the bladder, or chronic cystitis.
Chronic bladder inflammation causes three main symptoms:
An average person visits the toilet around 7 times a day. But if you suffer from chronic cystitis, you may need to urinate many times a day – in severe cases this can be up to 60 times during the day and up to 40 times during the night. It is of no surprise that this affects your daily life, making even a trip to the store something to be planned in advance.
Sense of urgency to urinate can be so strong that you may be afraid of losing control over your bladder. This can limit your daily activities, causing further reduction in quality of life.
You may feel sharp, cutting pain in the pelvic region. It may vary in strength, but it is usually continuous. The pain may become stronger whilst emptying the bladder or during sexual intercourse.
How does chronic cystitis develop?
A healthy bladder has a fine mucous protective layer that stops irritant substances in the urine from reaching the bladder wall. In chronic forms of cystitis this protective lining, known as the glycosaminoglycan layer (or GAG-layer), becomes damaged, so it fails to protect the bladder wall. Once this barrier is damaged, irritants from urine can reach the underlying structures and aggravate the neurons. This causes the symptoms we discussed above.
How can Gepan help?
Gepan is a pH neutral, sterile solution, containing chondroitin sulphate (0.2%), a natural component of the GAG layer.
Mode of action
Glycosaminoglycan normally binds water, creating a hydrophilic mucous membrane, the so-called GAG-layer. In this way, irritants from the urine are not in direct contact with the bladder wall.
A damaged GAG-layer can cause chronic bladder infection symptoms. Urine contains substances, such as potassium ions, that can irritate the tissue. This causes constant pressure, frequent urination and persistent pain.
Gepan contains a highly purified and specially prepared chondroitin sulphate. Alongside heparin and dermatan, chondroitin is one of the main components of the GAG-layer. That way Gepan replenishes the protective layer, protects the bladder wall, and relieves the discomfort.
Gepan’s effectiveness, safety and tolerability are confirmed by 286 patients with chronic cystitis.* The study showed that all the main symptoms (pain, urgency and frequency) were significantly reduced after three months of treatment. In addition to that, both doctors (84%) and patients (82%) were highly satisfied by the treatment.